Enfamil Enspire Optimum vs Gentlease

Enfamil Enspire Optimum vs Gentlease

Quick Comparison

Based on the information in this article, here’s a comparison table between Enfamil Enspire Optimum and Enfamil Gentlease:

Criteria/FeatureEnfamil Enspire OptimumEnfamil Gentlease
Nutritional Needs
ProteinEnsure adequate levels for growthEnsure adequate levels for growth
FatsNeeded for brain development and energyNeeded for brain development and energy
Vitamins and MineralsEssential vitamins and minerals like Vitamin D, calcium, and ironEssential vitamins and minerals like Vitamin D, calcium, and iron
Possible AllergiesContains lactoferrin (may not be ideal for milk allergies or lactose intolerance)Contains partially hydrolyzed nonfat milk and whey protein concentrate solids (suitable for sensitive stomachs)
Bottle Preparation Ease
Formula TypePowder vs. liquid concentratePowder vs. liquid concentrate
StorageSpecific storage requirements like refrigeration or shelf-stableSpecific storage requirements like refrigeration or shelf-stable
Expert OpinionsContains lactoferrin and MFGM, mimics breast milk nutrients, supports immune and brain (Influenster)Designed to ease gas and fussiness, closer to breast milk composition, non-GMO (What to Expect)
Personal ExperiencesContains lactoferrin for digestion and immunity, reduces gas, colic, or fussinessDesigned for sensitive tummies, contains partially broken down proteins, reduces gas and fussiness
Bottom LineCloser to breast milk with MFGM and Lactoferrin, supports growth and healthFocuses on easing gas, fussiness, and crying within 24 hours, contains partially broken-down proteins and less lactose

Making a decision about which baby formula to use can be challenging for parents, especially when there are multiple options on the market.

Two such products are Enfamil Enspire Optimum and Enfamil Gentlease. Both formulas have their specific benefits, and understanding these can help parents make an informed choice for their baby’s nutritional needs.

Enfamil Enspire Optimum is a premium formula offering optimal nutrition, with dual HMOs (2’FL & LnNT) to help support immune health and lactoferrin, an essential component found in breast milk.

On the other hand, Enfamil NeuroPro Gentlease is designed to ease feeding issues like gas and fussiness, while still providing complete nutrition during a baby’s first 12 months.

Key Takeaways

  • Enspire Optimum and Gentlease are two popular baby formulas from the Enfamil brand
  • Enspire Optimum contains dual HMOs and lactoferrin for optimal nutrition and immune support
  • Gentlease is specifically designed to address common feeding issues like gas and fussiness

Understanding Enfamil Enspire Optimum

Key Ingredients

Enfamil Enspire Optimum is a milk-based formula designed for full-term infants aged 0-12 months. Some essential ingredients of this formula include:

  • Non-fat milk
  • Lactoferrin (below 2%)
  • Vegetable oil
  • Whey protein
  • Protein-lipid concentrate
  • Polydextrose
  • Galactooligosaccharides
  • Mortierella Alpina oil
  • Crypthecodinium cohnii oil

In addition, Enspire Optimum contains various vitamins and minerals to support your baby’s overall health.


Enfamil Enspire Optimum offers several benefits for your baby, such as:

  • Immune support: The formula contains lactoferrin, a key immune-supporting protein found in breast milk.
  • Optimum Dual HMO: Enspire Optimum includes 2’FL and LnNT, two essential prebiotics that support immune health, also found in breast milk.
  • Omega-3 DHA: This formula contains the global expert-recommended amount of DHA, an essential omega-3 fatty acid for brain development.
  • #1 Pediatrician recommended brand: Enfamil is a recognized and trusted brand among pediatricians.

Potential Drawbacks

Despite the benefits, Enfamil Enspire Optimum might have some potential drawbacks:

  • Cost: Enspire Optimum may be significantly more expensive than other infant formulas available in the market.
  • Not ideal for sensitive babies: Babies with lactose intolerance or milk protein allergy may need to use an alternative formula.

Remember to consult with your pediatrician before switching formulas or starting your baby on Enfamil Enspire Optimum. They will help you make the best decision based on your baby’s specific needs.

Other Comparisons

Understanding Enfamil Gentlease

Key Ingredients

Enfamil Gentlease is a baby formula designed with key ingredients that are found in breast milk, which help meet your little one’s nutritional needs. It contains approximately 20% lactose as a source of carbohydrate, making it a gentler option for babies who may have lactose sensitivity.

  • Protein: Partially hydrolyzed nonfat milk and whey protein concentrate solids (from soy)
  • Fat: Blend of vegetable oils (palm olein, soy, coconut, and high oleic sunflower)
  • Carbohydrate: Corn syrup solids, lactose


Enfamil Gentlease offers several benefits to meet your baby’s needs:

  • Reduced lactose content: It has ~20% lactose as a source of carbohydrate, making it suitable for babies who may have lactose sensitivity.
  • Easy digestion: Partially broken down proteins make it easier on your baby’s tummy.
  • Nutrition: Formulated with essential nutrients like DHA, ARA, and choline to help support your baby’s brain development and overall growth.
  • Immune system support: Contains important vitamins and minerals to support your baby’s developing immune system.

Potential Drawbacks

While Enfamil Gentlease is designed to be a gentler formula for babies with lactose sensitivity, it’s essential to consider some drawbacks:

  • Not suitable for galactosemia: If your baby has been diagnosed with galactosemia, they should not consume this formula.
  • Higher cost: Enfamil Gentlease may have a higher cost compared to some other baby formulas available in the market.
  • Potential allergens: This formula contains soy, which might not be suitable for babies with soy allergies.

Other Comparisons

Direct Comparison

Nutritional Value

Enfamil Enspire Optimum and Enfamil Gentlease are both excellent choices for your baby’s nutrition, but they serve different purposes.

Enspire Optimum is formulated with dual HMOs (2’FL & LnNT) and lactoferrin, which are important components of breast milk and help support immune health. On the other hand, Gentlease is designed to ease fussiness, gas, and crying in infants within 24 hours of consuming the formula.


When it comes to cost, there may be some differences between Enspire Optimum and Gentlease. While specific prices may vary depending on the retailer and location, Enspire Optimum may be priced slightly higher since it includes added nutritional components like dual HMOs and lactoferrin.

Always keep your budget in mind when choosing a formula, but also consider the additional benefits each formula may provide for your baby’s specific needs.

Taste and Texture

Both Enfamil Enspire Optimum and Gentlease aim to provide a taste and texture that is palatable for babies.

However, taste and texture preferences can vary from one infant to another. If you’re trying to choose between these two options, you may want to base your decision on the nutritional benefits they provide rather than their taste and texture.

Keep in mind that it’s normal for babies to need some time to adjust when switching from breastfeeding or another formula.

Considerations Before Buying

In order to choose the right formula for your baby, there are several factors to consider. By evaluating your baby’s nutritional needs, potential allergies, and the ease of bottle preparation, you’ll be able to select the best option for your little one.

Infant’s Nutritional Needs

Newborns and infants require specific nutrients for proper growth and development. When comparing Enfamil Enspire Optimum and Gentlease formulas, make sure to check the nutritional content, including:

  • Protein: Ensure the formula contains adequate levels of protein, which is crucial for your baby’s growth.
  • Fats: Babies need fat for brain development and energy, so review the types and amounts of fats in the formulas.
  • Vitamins and minerals: Analyze the levels of essential vitamins and minerals, such as Vitamin D, calcium, and iron, to provide your baby with necessary nutrients.

Possible Allergies

Some infants have sensitivities or allergies to certain ingredients. The Enfamil Gentlease formula is designed to be gentler on a baby’s digestive system and contains partially hydrolyzed nonfat milk and whey protein concentrate solids, making it a suitable option for sensitive stomachs.

On the other hand, Enfamil Enspire Optimum contains lactoferrin, which may not be ideal for babies with milk allergies or lactose intolerance. Always consult your pediatrician before making a final decision.

Bottle Preparation Ease

Preparing bottles correctly and efficiently is important for busy parents. Consider these factors when choosing a formula:

  • Powder vs. liquid concentrate: Formula powders may be more time-consuming to prepare and require accurate measurements, while liquid concentrates tend to be quicker to mix. Pick the option that fits your lifestyle and convenience needs.
  • Storage requirements: Some formulas have specific storage requirements, such as refrigeration, while others may be shelf-stable. Keep storage limitations in mind when making a decision.

Remember to take into account your baby’s individual needs and preferences when selecting between Enfamil Enspire Optimum and Gentlease formulas.

Expert Opinions

When it comes to choosing between Enfamil Enspire Optimum and Enfamil Gentlease, it’s important to consider recommendations from experts and the specific needs of your baby.

Pediatricians often recommend Enfamil Enspire Optimum for its advanced formulation, striving to mimic the nutrient profile of breast milk as closely as possible. Key components like lactoferrin and MFGM are naturally found in breast milk and contribute to the formula’s benefits, such as immune and brain support (Influenster).

Enfamil Gentlease, on the other hand, is specifically designed to ease gas and fussiness. It has been popular among parents and pediatricians for providing quick relief to babies with sensitive tummies. The Gentlease formula has also been updated to be closer to breast milk composition and is now non-GMO (What to Expect).

Some parents have expressed satisfaction with Enfamil Enspire Gentlease, a combination of Enspire’s advanced formulation and Gentlease’s gentle ingredients. However, this specific formula may be harder to find (snippet 2). Please consult your pediatrician for a tailored recommendation that suits your baby’s needs and preferences.

To gather further insights, you can also refer to customer reviews on platforms like Amazon, where users discuss their experiences with both Enfamil Enspire Gentlease Infant Formula and regular Enfamil Gentlease (snippet 3).

Remember, it is always best to consult your pediatrician before making any changes to your baby’s diet or switching formulas, as they can provide expert advice and specific recommendations based on your baby’s needs.

Personal Experiences

When it comes to using Enfamil Enspire Optimum and Gentlease, it’s essential to listen to your baby’s needs and reactions. Both these formulas are designed to provide complete nutrition, but they do have some differences that may affect your baby’s experience.

For many parents, the Enfamil Enspire Optimum has been a game changer. With the addition of lactoferrin, a protein found in breast milk and colostrum, this formula seems to have helped with digestion and immunity issues.

You may notice that your baby is more comfortable after feeding and experiences fewer instances of gas, colic, or fussiness. The added lactoferrin could make this an excellent choice for your baby’s well-being.

On the other hand, Enfamil Gentlease has been a favorite of many parents as it’s specifically designed for babies with sensitive tummies.

If your baby struggles with gas or fussiness due to lactose sensitivity, Gentlease might be the way to go. It contains partially broken down proteins, which makes it easier for your baby to digest. Parents often report that their babies seem happier and more content after feeding when using this formula.

Now, as you try out these different formula options, remember that every baby is unique and might react differently to various types of formulas. Be patient, and don’t be afraid to consult your pediatrician if you’re unsure about which option is the best for you and your baby.

At the end of the day, the most important thing is to provide your little one with the nutrition they need to grow and thrive. Whether you choose Enfamil Enspire Optimum, Gentlease, or even a combination of both, always remember to enjoy every precious moment with your baby.


After comparing Enfamil Enspire and Enfamil Gentlease, you can now confidently make a decision based on your baby’s needs and your preferences. Remember to consider the ingredients, nutritional benefits, and suitability for your little one’s specific requirements.

Enfamil Enspire is designed to be closer to breast milk, with the inclusion of key components like MFGM and Lactoferrin. This formula also provides essential nutrients to support your baby’s growth and overall health. On the other hand, Enfamil Gentlease focuses on easing gas, fussiness, and crying within 24 hours due to its partially broken-down proteins and reduced lactose content.

To summarize, Enfamil Enspire Optimum might be a better fit for those looking to provide their baby with a formula closely resembling breast milk, while Enfamil Gentlease could be more suitable for babies experiencing digestive discomfort. Whichever option you choose, it’s always a good idea to consult with your pediatrician to ensure that the formula meets your baby’s needs.

Remember, when introducing a new formula, make the transition gradually, allowing your baby’s digestive system to adapt. Trust your instincts and observe your baby’s reactions, adjusting as needed.

Frequently Asked Questions

What is the main difference between Enspire Optimum and Gentlease?

Enspire Optimum is formulated to closely mimic the composition of breast milk, providing optimum nutrition for your baby. On the other hand, Gentlease is designed to ease fussiness, gas, and crying in infants while also providing essential nutrition for healthy development.

Which formula is closest to breast milk?

Enspire Optimum is the formula that is closest to breast milk. It contains important proteins like Lactoferrin, which supports immune health, and dual HMOs found in breast milk.

How do Enspire Optimum and Gentlease affect digestion?

Both Enspire Optimum and Gentlease are designed to be gentle on your baby’s digestive system. Enspire Optimum closely mimics the composition of breast milk, which is easily digestible, while Gentlease targets gas and fussiness. Gentlease is specifically formulated with lower lactose levels to ease digestion for infants who may be sensitive to lactose.

What are the key ingredients in Enspire Optimum?

Enspire Optimum contains Lactoferrin, an important protein that supports immune health, Milk Fat Globule Membrane, and Docosahexaenoic Acid (DHA), an essential fatty acid that supports brain development.

Which formula is better for reducing gas and fussiness?

Gentlease is specifically designed to reduce gas and fussiness. Enfamil Gentlease claims to be able to ease fussiness in infants quickly, in no more than 24 hours, after starting their feed with the formula.

Can you switch between Enspire Optimum and Gentlease easily?

Switching between different infant formulas should be done under the guidance of your baby’s healthcare provider. Since every baby’s needs are unique, it is important to consult with a professional before making any changes to their feeding routine.