Enfamil Enspire vs Enspire Optimum

Enfamil Enspire vs Enspire Optimum

Quick Comparison

Feature/AspectEnfamil EnspireEnfamil Enspire Optimum
DescriptionMilk-based formula fortified with iron for full-term infants aged 0-12 months.Similar to Enfamil Enspire but with the added advantage of dual HMOs (2’FL & LnNT) for enhanced immune health.
Key Ingredients– Lactoferrin (supports immune health)
– Non-fat milk
– Vegetable oil
– Whey protein
– Dual HMO (2’FL and LnNT)
– Lactoferrin (supports immune health)
– Omega-3 DHA
Nutritional BenefitsSupports growth and development. Contains MFGM components for brain development.Supports immune health with HMOs. Contains lactoferrin for respiratory and gut health. Contains Omega-3 DHA.
Ideal UsageSuitable for full-term infants from birth to 12 months. Resembles the nutritional composition of breast milk.Suitable for parents seeking advanced infant nutrition.
PackagingUsed to be available in power format in tubs or cases.Available in powder format in sizes like 20.50 oz tub or a case of four 20.50 oz tubs.
Ingredients ComparisonContains non-fat milk, lactoferrin, vegetable oil, whey protein, and other minerals and vitamins.Contains HuMO6 premium immune blend, 2’-FL and LNnT HMO, Vitamin C, E, Selenium, and Zinc.
Age RecommendationsDesigned for full-term infants aged 0-12 months.Designed for full-term infants aged 0-12 months.

Deciding on the best infant formula for your baby can be a confusing task, especially with multiple quality options available in the market. Enfamil, a leading brand in baby formulas, offers two highly sought-after formulas – Enfamil Enspire and Enspire Optimum.

Both of these options aim to provide the best possible nutrition for your little one, mimicking the benefits of breast milk.

Both Enfamil Enspire and Enspire Optimum are designed to be closest to breast milk in composition, containing crucial ingredients like lactoferrin to support immune health.

On the other hand, Enspire Optimum builds upon Enspire’s base formula by adding dual HMOs (2’FL & LnNT) and other essential components, offering optimal nutrition for your baby’s growth and development.

Enfamil Enspire Optimum Infant Formula delivers “premium nutrition like never before.” The product page mentions that their new “Optimum” formula is moving even closer to their ambition of getting as close to breast milk as possible.

Based on the information obtained from the Enfamil website, there is no explicit mention of Enfamil Enspire being replaced. However, they seem to have introduced or are promoting the “Enfamil Enspire Optimum” formula as they phase out the “Enfamil Enspire” formula.

Key Takeaways

  • Enfamil Enspire Optimum appears to be the replacement for Enfamil Enspire.
  • Enfamil Enspire and Enspire Optimum are top infant formulas aiming to provide nutrition similar to breast milk.
  • Enfamil Enspire contains lactoferrin, an essential component to support immune health.
  • Enspire Optimum enhances the Enspire formula by adding dual HMOs and additional components for optimal nutrition.

Understanding Enfamil Enspire

Product Overview

Enfamil Enspire is a milk-based, iron-fortified infant formula designed to provide optimal nutrition for full-term infants aged 0-12 months. This advanced formula is created to closely resemble breast milk’s nutritional profile and offers support for your baby’s immune health.


Enfamil Enspire offers various benefits to your baby’s overall development:

  • Immune support: Enspire contains lactoferrin, a protein that’s also found in colostrum and breast milk. Lactoferrin is essential for supporting your baby’s immune system and overall health.
  • Cognitive development: The formula consists of key ingredients that contribute to cognitive and neurodevelopment in infants.
  • Closeness to breast milk: Enfamil Enspire is designed to be the closest formula to breast milk, ensuring that your baby gets the essential nutrients for healthy growth and development.

Nutritional Value

Enfamil Enspire offers a balanced nutritional profile that caters to the needs of your growing baby:

  • Calories: This formula provides 20 calories per fluid ounce, making it an ideal choice for your baby’s energy requirements.
  • Essential nutrients: Enfamil Enspire is fortified with important nutrients, such as vitamins C & E, selenium, and zinc, further supporting your baby’s immune health.
  • MFGM: The formula includes Milk Fat Globule Membrane (MFGM), promoting cognitive development in infants.

In providing your baby with Enfamil Enspire, you ensure they receive comprehensive support for growth, immune health, and cognitive development as they transition into early childhood.


Understanding Enspire Optimum

Product Overview

Enspire Optimum is a 20 Cal/fl oz milk-based, iron-fortified, routine formula designed for full-term infants aged 0-12 months. This premium formula is an updated version of the original Enspire, as the company is phasing out the original product.


Enspire Optimum offers several advantages for your baby’s health and well-being:

  • Dual HMOs (2’FL & LnNT): These human milk oligosaccharides are essential components of breast milk that support immune health.
  • Lactoferrin: Previously only largely available in breast milk, this protein supports your baby’s immune health.
  • Vitamins and Minerals: Enfamil Enspire Optimum includes essential vitamins and minerals such as Vitamin C & E, Selenium, and Zinc, all of which contribute to overall development and growth.

Nutritional Value

The nutritional value of Enfamil Enspire Optimum comes from its carefully selected ingredients:

  • Non-fat Milk: This forms the basis of the milk-based formula and provides essential nutrients.
  • Vegetable Oil: A source of healthy fats for your baby.
  • Whey Protein & Protein-Lipid Concentrate: These ingredients provide vital protein and support your baby’s growth and development.
  • Polydextrose & Galactooligosaccharides: These components act as dietary fibers and prebiotics that aid in digestion and gastrointestinal health.
  • Mortierella Alpina Oil & Crypthecodinium Cohnii Oil: These oils supply essential fatty acids important for brain and eye development.

Remember to consider these aspects as you consider Enfamil Enspire Optimum for your baby’s nutritional needs.


Comparative Analysis


Both Enfamil Enspire and Enspire Optimum are designed to cater to the nutritional needs of your infants, specifically full-term infants aged 0-12 months. They are milk-based, iron-fortified, and have a 20 Cal/fl oz ratio, providing your little one with essential nutrients and energy for healthy growth.

Additionally, both formulas contain lactoferrin, a component previously only largely found in breast milk, which helps in supporting immune health. They also feature naturally occurring MFGM components, which play a crucial role in your baby’s brain development.


While Enfamil Enspire and Enspire Optimum share many similarities, the key difference between the two lies in the fact that Enspire Optimum comes with an added component called HuMO6 premium immune blend. This blend includes 2′-FL and LNnT HMO, Vitamin C & E, Selenium, and Zinc, further contributing to your baby’s immune health.

It is worth mentioning that Enspire Optimum will soon be the only available product between the two, as the original Enspire is being phased out.

Price Comparison

Regarding pricing, both formulas are sold in 20.50 oz tubs with a cost of $0.30 per fl oz. However, the Enfamil Enspire Optimum is priced slightly higher at $43.99 per tub, while the original Enfamil Enspire may have a slightly lower cost.

To help you further compare the prices and make an informed decision, here’s a tabular representation of the cost breakdown:

ProductPrice per TubPrice per fl oz
Enfamil EnspireVaries*$0.30
Enfamil Enspire Optimum$43.99$0.30

*The price of the original Enfamil Enspire may vary depending on availability, as the product is being phased out.

Please note that the pricing information may change over time, and it is always a good idea to compare the latest prices before purchasing.

Mothers’ Testimonials

One mother on Reddit mentioned that she supplemented her first baby with Enfamil Enspire and found it helpful. Now, she’s planning to use it again for her second child and has discovered the Enfamil Enspire Optimum formula. Although there isn’t much comparison information available between Enspire and Enspire Optimum, she reached out to Enfamil for clarification.

Another mother, Yen P., gave Enfamil Enspire Infant Formula a perfect 5/5 rating on Influenster. She appreciated that the formula goes beyond standard ones, striving to mimic the nutritional profile of breast milk.

On Forbes Health, a mother shared her experience of switching from breast milk to Enfamil formula. She felt secure in her decision, as health professionals highly recommended Enfamil.

TheBump.com also featured mothers praising Enfamil Enspire for its contents. They love that the formula has immune-strengthening proteins and prebiotics and probiotics to help with digestion. Furthermore, Enspire contains lactose as its only sweetening agent, much like breast milk, rather than the corn maltodextrin found in other formulas.

In summary, numerous mothers have shared their positive experiences using Enfamil Enspire products when supplementing or transitioning from breast milk. They appreciate the formula’s efforts to emulate the benefits of breast milk through high-quality ingredients and added nutrients.


In your quest to compare and choose between Enfamil Enspire and Enfamil Enspire Optimum, it’s essential to consider the following factors:

Key nutrients: Both Enfamil Enspire and Enspire Optimum provide crucial nutrients to support your baby’s healthy growth and development. However, Enspire Optimum has lactoferrin, which was previously only largely available in breast milk and helps support immune health.

Closest to breast milk: Enspire is known to be the closest formula to breast milk due to its ingredients. This could be especially beneficial if you supplement your baby’s diet with formula or transitioning from breastfeeding.

Age range: Both formulas are suitable for full-term infants aged 0-12 months. Keeping your baby’s age in mind when choosing a formula can ensure they receive the appropriate nutrition for their stage of development.

Price: Enfamil Premium A2 Infant Formula, which is part of the Enfamil product line, costs about $1.90 per ounce. Comparing the prices of Enspire and Enspire Optimum can help you choose the option that fits your budget while meeting your baby’s nutritional needs.

Ultimately, your decision should be centered around your baby’s specific needs and preferences. Consult with your pediatrician and try both options to determine which is more suitable for your baby and their unique requirements.

Frequently Asked Questions

What are the main differences between Enspire and Enspire Optimum?

Enspire Optimum stands out with HuMO6 Premium Immune Blend, which contains 2′-FL and LNnT HMO, Vitamin C & E, Selenium, and Zinc. This blend is specifically designed to support immune health. Enfamil is phasing out the original Enspire, so soon, you’ll only find Enspire Optimum available.

How do the ingredients of Enspire Optimum compare to other Enfamil formulas?

Enspire Optimum is unique because it contains lactoferrin, an ingredient found in breast milk that supports immune health. Additionally, Enspire Optimum contains naturally occurring MFGM components, which are important building blocks of the brain.

Which formula is closest to breastmilk: Enspire or Enspire Optimum?

Both Enspire and Enspire Optimum aim to provide nutrition close to breast milk. However, the Optimum version boasts a premium immune blend, making it slightly closer to breast milk in terms of nutritional value.

Is Enspire Optimum suitable for breastfed babies?

Enspire Optimum is designed for full-term infants aged 0-12 months and is suitable for breastfed babies. However, it’s always best to consult your baby’s doctor before introducing any formula, especially if your baby has specific dietary needs or requirements.

What are some common places to buy Enspire and Enspire Optimum?

You can find Enspire Optimum at major retailers and online stores, such as Amazon, Walmart, and Target, as well as Enfamil’s official website. As Enspire is being phased out, its availability will become increasingly limited.

What do customers think of Enspire Optimum based on reviews?

While I cannot provide direct quotes from customer reviews, it’s worth noting that opinions on infant formulas can vary greatly depending on individual experiences and babies’ specific needs. To get a better understanding of how Enspire Optimum has worked for others, consider reading reviews on retailer websites and participating in online discussions with other parents.