Enfamil vs Enspire

Enfamil Infant vs Enspire 1

Quick Comparison

Feature/AspectEnfamil InfantEnfamil Enspire
Brand OverviewTrusted formula used by parents for years, designed for babies from birth to 12 months.Newer offering aiming to closely mimic the composition of breast milk.
Key FeaturesDHA and ARA for brain and eye health. Dual prebiotics for gut and immune system health.Enriched with MFGM.<br>- Higher vitamin D content. Dual HMO (2’FL and LnNT) for immune health. Lactoferrin for immune support. Omega-3 DHA for brain development.
CompositionProtein: Nonfat milk and whey protein concentrate. Carbohydrates: 100% lactose. Fats: Palm oil, soy oil, high oleic safflower oil, and coconut oil.Similar protein, carbohydrate, and fat sources as Enfamil Infant. Enriched with MFGM and lactoferrin.
Health BenefitsComplete nutrition for the first year. Supports brain and eye development. Boosts immune system.Mimics breast milk composition. Supports cognitive development and immunity. Contains MFGM for potential cognitive benefits.
PricingTypically around $27 for a 21.1-ounce tub.Generally more expensive due to the addition of MFGM.
SuitabilitySuitable for most babies without specific health issues.Designed to closely resemble breast milk, making it suitable for supplementing breastfed babies.

Choosing the right formula for your baby can be a daunting task, especially with a wide variety of options available in the market. In this article, we will take a closer look at two popular choices: Enfamil Infant and Enfamil Enspire.

Both formulas are from the well-known brand Enfamil and claim to provide essential nutrients for your baby’s growth and development.

Enfamil Infant is a trusted formula that has been used by parents for years. It is designed to provide complete nutrition for babies from birth to 12 months, with key nutrients and vitamins, such as DHA, ARA, and iron.

On the other hand, Enfamil Enspire is a newer offering from the brand that also aims to support your infant’s overall development but adds enriched MFGM and a higher vitamin D content in its formulation.

This comparison will help you understand the differences between Enfamil Infant and Enspire to make an informed decision about which one to choose for your baby’s nutritional requirements based on their specific needs.

Key Takeaways

  • Enfamil Infant and Enspire are both popular baby formula options
  • Enspire is enriched with MFGM and has a higher vitamin D content than Enfamil Infant
  • Understanding the differences between the two can help you make the best choice for your baby’s needs

What is Enfamil Infant?

Enfamil Infant is a milk-based infant formula designed to provide complete nutrition for babies aged from birth to 12 months. It’s suitable for babies with no health issues and is an excellent choice for your baby’s everyday feeding needs.


Enfamil Infant is made from nonfat milk and whey protein concentrate, serving as its primary protein source. It uses 100% lactose as a carbohydrate and includes a blend of palm oil, soy oil, high oleic safflower oil, and coconut oil for its fat content. Some key components include:

  • Protein: Nonfat milk and whey protein concentrate
  • Carbohydrates: 100% lactose
  • Fats: Palm oil, soy oil, high oleic safflower oil, and coconut oil

Health Benefits

Enfamil Infant offers your baby numerous health benefits, including:

  • Complete nutrition: It provides essential nutrients necessary for proper growth and development during the first year, such as vitamins D, C, and E, as well as brain-nourishing DHA.
  • Immune support: Enfamil Infant contains essential elements that support the development of your baby’s immune system.
  • Suitable for most babies: As a standard infant formula, it’s designed for babies with no particular health issues, making it a safe choice for your little one.


Enfamil Infant’s prices may vary depending on the package size and brand promotions. Comparatively, Enfamil Enspire is generally more expensive than Enfamil Infant due to the addition of the MFGM component. To find the best price for your baby’s formula, it’s a good idea to compare multiple retailers and keep an eye on any available discounts or offers.

Enfamil Infant Comparisons

What is Enfamil Enspire?

Enfamil Enspire is a premium infant formula designed to provide complete nutrition for your baby. It’s specially formulated to closely mimic the composition of breast milk, offering essential nutrients needed for proper growth and development.


Enfamil Enspire contains a blend of nonfat milk and whey protein concentrate, with 100% lactose as its carbohydrate source. The fat content comes from a combination of palm oil, soy oil, high oleic safflower oil, and coconut oil. Additionally, Enspire is enriched with essential nutrients such as:

  • Dual HMO (2’FL and LnNT): These prebiotics are found in breast milk and help support your baby’s immune health.
  • Lactoferrin: This immune-supporting protein is also present in breast milk, providing an additional boost to your baby’s immunity.
  • Omega-3 DHA: Enspire meets the global expert-recommended amount of DHA, an essential fatty acid that supports brain development.

Unique Features

Enfamil Enspire stands out from other infant formulas due to a few key features:

  • MFGM: This formula is enriched with milk fat globule membrane (MFGM), which has been shown to support cognitive development.
  • Lactoferrin: Enspire includes lactoferrin, a key immune-supporting protein found in breast milk, further boosting its nutritional profile.
  • Dual HMO Prebiotics: The presence of two types of human milk oligosaccharides (HMOs) helps promote a healthy gut microbiome and supports overall immune health.


Enfamil Enspire is a premium formula, and its pricing reflects that. It may be more expensive compared to other infant formulas, including Enfamil Infant. It is essential to consider your budget and your baby’s specific needs when deciding which formula to choose.

Remember, your pediatrician is an excellent resource to consult when making decisions about your baby’s nutrition.

Enfamil Enspire Comparisons

Enfamil Infant vs Enspire

Direct Comparison: Enfamil Infant vs Enspire

Nutritional Differences

When comparing Enfamil Infant and Enspire, you’ll notice that both formulas contain the same ingredients. The key difference lies in Enfamil Enspire being enriched with MFGM, while Enfamil Infant is not. In terms of vitamin D levels, Enspire has 70/100cal, whereas Enfamil Infant has 60/100cal.

Price Differences

As you consider the cost, be prepared that Enfamil Enspire tends to be more expensive than Enfamil Infant. This price difference can be attributed to the addition of MFGM in Enspire, which is associated with extra benefits for your baby’s development. Make sure to compare the prices of both formulas at your preferred retailer or online to choose the most suitable option for your budget.

Suitability Perspectives

Your baby’s specific needs play a vital role in determining the suitability of either Enfamil Infant or Enspire. Enfamil NeuroPro is considered the best formula from Enfamil, containing 30 nutrients designed to support your baby’s development. It has an expert-recommended amount of DHA for brain growth and a dual prebiotic blend for immune support.

However, if your baby has specific dietary requirements or sensitivities, it’s essential to consult with a healthcare professional before choosing one formula over the other. They can guide you in making the best decision for your baby’s individual needs.


In comparing Enfamil Enspire and Enfamil Infant, you’ll find that both formulas use the same ingredients. However, Enfamil Enspire is enriched with MFGM, which is not present in Enfamil Infant. This addition in Enspire makes it a closer match to the components found in breast milk, providing your baby with exceptional nutrition.

As you consider which formula is best for your baby, remember that both Enfamil Enspire and Enfamil Infant have been designed to meet their nutritional needs. Enspire may be a better choice if you’re looking for a formula with additional ingredients like lactoferrin, also found in breast milk and colostrum.

Ultimately, the choice between Enfamil Enspire and Enfamil Infant depends on your baby’s individual needs and your preferences as a parent. Ensure to consult with your pediatrician for the most personalized guidance on which formula is the best fit for your little one.

Frequently Asked Questions

What are the main differences between Enfamil Infant and Enspire?

Enfamil Infant and Enspire share similar ingredients. However, Enspire is enriched with Milk Fat Globule Membrane (MFGM), which is not found in the Infant formula. MFGM has been shown to have potential benefits for cognitive development and immunity support.

How does Enspire compare to other formulas like Similac?

Enspire contains a higher percentage of DHA, an important fatty acid for brain development, compared to Similac (0.32% vs 0.15%). Additionally, Enspire is enriched with MFGM, whereas Similac does not include this component.

Is Enfamil NeuroPro a better choice than Infant or Enspire?

Enfamil NeuroPro, like Enspire, contains MFGM. Your choice between NeuroPro, Infant, or Enspire may depend on your baby’s specific needs and your pediatrician’s recommendation. Consult your baby’s doctor to determine the best formula choice for your baby.

Which Enfamil formulas are best for newborns?

Enfamil Infant, Enspire, and NeuroPro can all be suitable for newborns. It’s important to discuss your baby’s needs with their doctor to determine the best choice, as each baby’s nutritional requirements may vary.

What unique features does Enfamil Enspire offer?

Enfamil Enspire’s unique features include MFGM and a higher percentage of DHA compared to some other formulas. These components may offer potential benefits for cognitive development and immune system support, making Enspire an attractive option for parents seeking a formula that closely mimics breast milk.

Can Enfamil Enspire be a suitable choice for breastfed babies?

Enfamil Enspire can be a suitable choice for supplementing breastfed babies. Its components, such as MFGM and higher DHA content, strive to offer a formula that closely resembles breast milk. However, it is important to consult your baby’s pediatrician before introducing any formula to ensure it meets your baby’s needs.